Hydroxychloroquine and Antimalarials

Synthetic Antimalarials

Marine Antimalarials

Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of marine chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with particular emphasis on recent discoveries....

Hydroxychloroquine screening.

A lmony et al report in this issue of the BJO (p 569) the use of a threshold Amsler grid (TAG) as a screening tool for asymptomatic patients taking hydroxychloroquine (HCQ). They studied 56 patients taking HCQ and 12 controls. Patients were tested with a ‘‘white on black’’ Amsler grid (AG), a ‘‘red on black’’ AG (RAG), and the threshold AG (TAG). TAG uses cross polarising filters to reduce the ...

Drug Antibiotic Interactions-antimalarials

The antimicrobial effects of four antimalarials were determined. The effect of the chosen drugs when combined with a selected number of antibiotics was studied on Staphylococcus aureus and Escherichia coli to determine the types of interaction. Most antimalarials showed either no effect or a synergistic action. However, some exhibited antagonistic effects, which may be either due to some physic...

Hydroxychloroquine and colchicine induced myopathy.